The course draws connections between the orderly and chaotic behavior of simple and complex systems, laying the foundations of statistical equilibrium and equilibrium thermodynamics. The different phases of matter (gases, liquids, solid) assumed by bulk classical interacting particles and their transitions are discussed in this approximation. Properties of non-interacting quantal systems are expressed in terms of partition functions, for gases of simple and complex particles. Non-equilibrium statistical behavior of multi-particle systems leads to diffusion and other transport phenomena. Reading assignments and homework. Two weekly lectures of 75 minutes. Cross listed with CHE 455.
This course teaches the principles of modern cell and tissue engineering with a focus on understanding and manipulating the interactions between cells and their environment. After a brief overview of Cell and Tissue Engineering, the course covers 5 areas of the field. These are: 1) Physiology for Tissue Engineering; 2) Bioreactors and Biomolecule Production; 3) Materials for Tissue Engineering; 4) Cell Cultures and Bioreactors and 5) Drug Delivery and Drug Discovery. Within each of these topics the emphasis is on analytical skills and instructors will assume knowledge of chemistry, mass transfer, fluid mechanics, thermodynamics and physiology consistent with the Cell and Tissue Engineering Track in BME. In a term project, students must present written and oral reports on a developing or existing application of Cell and Tissue Engineering. The reports must address the technology behind the application, the clinical need and any ethical implications.
Course Description: Elements of sustainable chemical processes. Bulk and fine chemicals derived from renewable resources-- e.g. carbohydrates, animal fats, plant seeds, lignocellulose, algae, and carbon dioxide. Use of environmentally benign solvents-- e.g. ionic liquids, supercritical carbon dioxide, fluorous solvents, and liquid polymer-- for chemical reactions and separations. Chemical reactions activated by unconventional means-- e.g. ball milling, microwave heating, and ultrasound irradiation-- requiring minimum energy, catalysts, and solvents. Polymers produced with monomers from renewable resources, designed for recovery and recycling beyond intended service. Chemical and enzymatic catalysis enhanced by process integration to minimize the need for product separation and purification. Microreactor technologies to maximize rates of heat & mass transfer, chemical reaction rates, product yields and selectivity, in addition to facilitating process control, optimization, and scale-up.
This course will explore the bioprocesses involved in producing a biopharmaceutical product (therapeutic proteins, cell therapy products, and vaccines). The course will take a stepwise journey through a typical production process from the perspective of a Bioprocess Engineer, starting with cell culture and moving downstream through purification and final fill. Engineering concepts involved in bioreactor design and control, cell removal/recovery operations, and protein purification will be examined. The course will also provide an introduction to the analytical methods used to test biopharmaceutical products for critical quality attributes The role of the regulatory agencies, like the US Food and Drug Administration, and the regulations that govern the industry will be introduced throughout the course in the context of the bioprocess to which they relate. Graduate students will need to complete a semester-end project in order to receive graduate credit for the course.
The life science and engineering principles underlying biotechnology processes; established biotechnology processes including microbial and enzyme conversions, metabolic pathways, and fermentation kinetics; tools for biotechnology development including the recombinant DNA and monoclonal antibody techniques; emerging areas at the forefront of biotechnology, including immune technology and tissue and organ cultures.
Introduction to the topic: Thermodynamics and Statistical Mechanics. In the beginning macroscopic thermodynamics including phase equilibria and stability concepts will be covered followed by material related to the principles of statistical mechanics. Applications to various modern areas of the topic will be examined including the Monte Carlo simulation method, critical phenomena and diffusion in disordered media. The course will require completion of a project as well as regular homework assignments.
This course emphasizes the fundamental physics of polymer melts, solutions, networks, and glasses. Topics include: molecular weight and size, chain conformations, thermodynamics of polymer blends and solutions, networks and gelation, polymer dynamics and the glass transition, and morphology and order of semicrystalline polymers. Experimental methods will also be covered including viscometry, size exclusion chromatography, light scattering, scanning calorimetry and dynamic mechanical analysis. OFFERED ODD YEARS
Graduate and advanced undergraduate course on surface-specific analytical techniques. The first few lectures of the course will cover basic thermodynamics and kinetics of solid-liquid and solid-gas interfaces, including surface energy and tension, surface forces, adsorption and chemisorption, and self-assembly. The rest of the class will focus on surface spectroscopy and microscopy, including X-ray and UV photoelectron spectroscopy, Auger spectroscopy, secondary ion mass spectrometry, IR and Raman spectroscopy/microscopy and scanning probe microscopy.
The goal of this course is to provide a succinct introduction to the different means of producing energy. The first and second laws of thermodynamics are reviewed to introduce the concepts of conservation of energy and efficiency. Then these concepts are applied to a number of different energy technologies, including wind, hydroelectric, geothermal, fuel cells, biomass, and nuclear. For each type of technology, a technical introduction is given so that the student will understand the governing scientific principles.
This course introduces students to the highly interdisciplinary field of biosensors, with focus on electrochemical transduction. After an overview of the fundamental principles, the course will introduce various strategies to apply the scientific theory and mechanisms to practical issues such as immunoassays, detection of DNA mutation or environmental toxins, metabolic activity, and in-vivo neuronal signal monitoring. The students will be exposed to recent publications that highlight key advances in this field and learn how various chemical, biological and engineering concepts are used in synergy to achieve state-of-the-art sensing of important biological molecules. Emphasis is placed on active participation by students, including literature presentations, critical evaluation of articles, concise technical writing and in-depth discussions.